http://www.newscientistjobs.com/jobsNew Scientist Jobshttp://www.newscientistjobs.com/jobs/job/technical-delivery-manager-md-maryland-200642313.htmFri, 20 Nov 2009 22:00:00 +0000196373My company shares my passion for helping to improve human health around the world. This is My MedImmune. Those who join MedImmune feel a sense of ownership about their future. They thrive with a recognized leader in the biotechnology industry and the wholly-owned subsidiary of AstraZeneca plc. Here, you will join passionate professionals who advance science, technology and medicine to develop products designed to help people live better lives. You will excel in an environment characterized by respect, integrity and growth opportunities that encourages both individual contribution and collaborative entrepreneurial thinking. Our products and/or product candidates are designed to address areas of need in infection, oncology, respiratory disease and inflammation, cardiovascular/gastrointestinal disease and neuroscience. Explore a MedImmune career as we strive to better more lives, more often, around the world. Title: Technical Delivery Manager Location: MD, Gaithersburg - Corporate Headquarters Req: 02109 Job Description Position will work in IT addressing the business technology needs within the area of Medical and Regulatory Affairs. Position will be responsible for understanding business problems and working with relationship managers, business analysts and technical teams to develop technology solutions in support of business needs. In addition, position will be responsible for overseeing technology solutions; implementing system-based solutions; and managing vendor partners and internal resources in the delivery and support of technology to satisfy MedImmune's business capability needs. Position will be responsible for technical oversight and management of projects. Position will own technical requirements definition based on functional requirements and taking the solution blueprint, in conjunction with the user requirements, and turning it into a detailed design or configuration. Position will assess the scope of new project efforts by estimating the work involved, resources required and time line for technical delivery efforts. Position owns solution prototyping and change management, blueprinting (fit/gap) and quality assurance; manages the development and delivery activities within SDD in support of project and non-project activities. Has direct responsibility for the overall success of the assigned project and deliverables, either through direct participation or oversight. Projects may include new applications and modules, major or minor enhancements to existing applications or modules and product upgrades. Position will work with business owners, relationship managers and IT to manage the development to production and the production to operations activities following established methodology. Activities include internal code reviews, testing, supporting user acceptance testing, developing a support approach, application training, disaster recovery plans, application process maps and others as defined by the IT PMO. Position will keep customers (to include business owners, relationship managers, and internal IT management) apprised of progress, issues, and risks in a timely manner. Position will practice risk management strategies to ensure that project commitments are realistic and met. Position will participate in the establishment and implementation of SDLC methodologies, ITIL processes and IT PMO processes and ensure that IT projects adhere to those standards and meet customer expectations International travel may be required. Additional requirements for Medical and Regulatory Affairs include: Experience with Medical and Regulatory Affairs in a pharmaceutical or biotech environment. Clinical trials knowledge. Experience with data warehousing and data mining. Skills: Demonstrated ability to manage software development teams, implementation of off the shelf software packages, and interdependencies within an IT development organization. Demonstrated ability to manage cost, schedule, and performance of IT development projects and departments. Demonstrated ability to manage different development resources to include, internal, external, contracted staff augmentation resources, and outsourcing partners. Ability to collaborate and engage IT stakeholders including IT security, Validation/QA, IT Infrastructure, and Enterprise Architecture as needed. Proven ability to identify, manage and mitigate issues and risks. Demonstrated oral and written communication skills. Experience presenting project information in a formal and informal setting. Demonstrated focus on meeting customer expectations and working with a customer service mindset. Demonstrated interpersonal skills with experience managing diverse teams. Demonstrated ability to staff and develop individuals and teams. Demonstrated commitment to staff development and retention. Demonstrated ability to conduct facilitated sessions with end users and business owners in order to define requirements and review project progress. Demonstrated skills in problem identification, isolation and resolution through the use of analysis, troubleshooting and other like techniques. Experience coaching staff on problem resolution techniques Functional Knowledge is necessary in the following areas: Biotech or Pharmaceuticals; Validated Systems Environments; Sarbanes-Oxley Requirements; Data and Application Security; Business Intelligence Processes and Methodology knowledge is necessary in the following areas: Familiarity with ITIL; SDLC processes to include rapid and waterfall development; Project management of multiple development projects; Data Analysis. Experience with electronic publishing processes (e.g. eCTD and other formats), document management (Documentum, LiveLink, etc) is highly desirable. Technical Skills are necessary in the following areas: Application Platforms (SharePoint, SharePoint Portal Server, SharePoint Server 2007, Web Logic, IIS). Application Development (XML, WebServices, Middleware such as BizTalk or BEA Aqua Logic); MS Office Suite of Products; Database and Business Intelligence (Data warehousing, Oracle, TOAD or other similar, SQL Server, MS Access); Development Applications (Visual Studios Team Services, Development management tool such as Rational or visual studio, etc.); Programming Languages (SQL, PL/SQL, Transact-SQL, C#) JOB REQUIREMENTS: Job Requirements Education: Bachelor's degree from accredited college or university is required. Bachelor's or master's degree in computer-related curriculum is desired. Experience: 6+ years of work experience; 4-5+ years of IT work experience, with progressively more responsibility; Proven track record of managing and coordinating several projects simultaneously while delivering on time, on schedule, and meeting customer expectations; Experience project planning from project inception through transition to operational support; 1-2 years in a pharmaceutical, biotech, or consumer goods environment; 2-3 years of managing technical resources to include internal and vendor partners; Ability to provide leadership, management and technical expertise to a culturally diverse, technically-oriented staff If you are interested in this position please click the Apply Now button below and search for Req #. 02109. MedImmune is an Equal Opportunity Employer and does not discriminate on the basis of race, color, religion, gender, age, national origin, disability, veteran status, or any other characteristic protected by federal, state or local law. http://www.newscientistjobs.com/jobs/job/research-scientist-imclone-systems-110490-new-york-ny-ny-new-york-200641018.htmFri, 20 Nov 2009 20:54:25 +0000196364A leader in therapeutic antibodies, ImClone Systems is committed to advancing oncology care by developing a portfolio of novel targeted biologic treatments designed to address the medical needs of patients with a variety of cancers. Founded 25 years ago, ImClone Systems has a rich culture of biotechnology innovation and leading-edge medical science. Our deep expertise in molecular biology, oncology, genomics and antibody engineering has helped us establish a robust pipeline of products that are in various stages of clinical development and span virtually all major solid tumor types. ImClone Systems is recruiting for a skilled and experienced individual to join our team of drug discovery as a Research Scientist. The successful candidate will be a highly motivated team player with a commitment to quality, and attention to detail, strong problem solving skills, and the ability to work productively. ESSENTIAL DUTIES AND RESPONSIBILITIES 1. ELISA and in vitro assays that measure antigen-specific cellular immunity 2. In vitro cell binding, flow cytometry, and pharmacological assays 3. Lymphocyte isolation and culture 4. Hands-on experience in running animal experiments 5. Basic molecular biology knowledge ESSENTIAL KNOWLEDGE, SKILLS, EXPERIENCE 1. BS or MS degree with strong background in immunology and tumor biology. 2. 3+ years for BS and 2+ years for MS with hands-on laboratory research experience. 3. Tumor Immunology, Immunohistology and animal handling experience a must. 4. Working knowledge of cell culture, immunology and related assays. http://www.newscientistjobs.com/jobs/job/research-faculty-computational-and-systems-biology-ny-new-york-200645874.htmFri, 20 Nov 2009 20:25:10 +0000196361Research Faculty Computational and Systems Biology The Computational Biology Program (cbio.mskcc.org) at MSKCC (ski.edu) seeks innovative investigators for tenure-track positions at the Assistant, Associate, or Full Professor level. Pursue basic research, solve biological problems with major emphasis on computational methods, and build active bridges to experimental and clinical research. Actively participate in building out research programs at one of the best clinical-scientific institutions in the world. Work in MSKCC’s new Zuckerman Research Center, on Manhattan’s Upper East Side, in close proximity to Rockefeller University and the Cornell Weill Medical College. Train graduate students in the Gerstner Sloan-Kettering Graduate School (sloankettering.edu), the Weill Cornell Graduate School of Medical Sciences and in tri¬-institutional graduate programs. Areas of special interest include chemical biology, physiology, developmental biology, neurobiology, genetics and cancer biology. Applicants should have a doctoral-level degree and the potential to develop an independent, interdisciplinary research program. MSKCC offers a highly interactive, supportive and dynamic research environment with programs in Computational Biology, Developmental Biology, Molecular Pharmacology & Chemistry, Cancer Biology & Genetics, Structural Biology, Immunology, Cell Biology, Molecular Biology, and Human Oncology and Pathogenesis, as well as unparalleled clinical programs in cancer research, treatment and prevention. E-mail your application (PDF) by clicking Apply Now below as soon as possible in December 2009 but no later than January 10, 2010. Detailed instructions at cbio.mskcc.org/faculty-search/. Need more information? E-mail Dwana Agosto: agostod@mskcc.org Department Chair: Chris Sander. MSKCC is an affirmative action, equal opportunity employer. http://www.newscientistjobs.com/jobs/job/associate-scientist-iiscientist-i-md-maryland-200645868.htmFri, 20 Nov 2009 19:16:57 +0000196350My company shares my passion for helping to improve human health around the world.” “This is My MedImmune.” Those who join MedImmune feel a sense of ownership about their future. They thrive with a recognized leader in the biotechnology industry and the wholly-owned subsidiary of AstraZeneca plc. Here, you will join passionate professionals who advance science, technology and medicine to develop products designed to help people live better lives. You will excel in an environment characterized by respect, integrity and growth opportunities…that encourages both individual contribution and collaborative entrepreneurial thinking. Our products and/or product candidates are designed to address areas of need in infection, oncology, respiratory disease and inflammation, cardiovascular/gastrointestinal disease and neuroscience. Explore a MedImmune career as we strive to better more lives, more often, around the world. Title: Associate Scientist II/Scientist I Location: CA, Mountain View - NON SALES Req: 02056 Position Summary: Major Duties and Responsibilities (including supervising others): We are seeking a highly motivated independent individual to join our formulation team aimed at formulation development for biologics including protein and live viruses. The individual will be working with the team focusing on formulation studies and characterizations for liquid or solid dosage formulations. The essential responsibilities will include planning and executing pre-formulation and formulation studies, developing and performing biophysical, biochemical and biological analyses. An ability to work independently and have effective organization and communication skills is essential. Special Skills/Abilities: Expertise in pre-formulation and formulation of proteins and antibodies required. Hands on expertise in analytical techniques including HPLC-SEC, RP-HPLC, FTIR, fluorescence assays, DSC/mDSC are required. A prior experience in ajuvant formulation development is a plus. Experiences with solid state analyses such as Karl-Fischer, TGA, DVS, particle sizing desired. Excellent oral and written skills required. Job Complexity: Medium-High. JOB REQUIREMENTS: Supervision: Work is performed with minimal supervision. (supervision required, level of independence) Requirements/Qualifications: Education: Degree in Chemistry, Chemical Engineering, Pharmaceutical Sciences, Biochemistry, Biophysics. Experience: Ph.D. + 0-3 yrs, M.S. + 8-10 yrs, B.S. + 10-13 yrs. If you are interested in this position please click the Apply Now button below. Req #. 02005 MedImmune is an Equal Opportunity Employer and does not discriminate on the basis of race, color, religion, gender, age, national origin, disability, veteran status, or any other characteristic protected by federal, state or local law. http://www.newscientistjobs.com/jobs/job/faculty-positions-cancer-biology-fl-florida-200645280.htmFri, 20 Nov 2009 13:34:56 +0000195084The Donald A. Adam Comprehensive Melanoma Research Center at the Moffitt Cancer Center is seeking laboratory-based faculty members with a Ph.D., M.D. or M.D.-Ph.D. with an interest in melanoma research. The prospective candidates will be appointed at the Assistant, Associate or Senior Member level, and it is expected that they would establish an independent funded laboratory research program concentrating on translational investigation in the fields of cancer stem cells, angiogenesis, metastasis, tumor microenvironment, apoptosis or the cell cycle. While candidates working on any cancer type will be considered, preference will be given to those with an interest in melanoma research. An outstanding start-up package is available, as well as a highly competitive salary and excellent lab space. A specific attraction is the opportunity to interact with ongoing well-funded research programs in molecular oncology, drug discovery, population science and translational immunology/immunotherapy. The Comprehensive Melanoma Research Center brings together clinicians, basic and translational scientists at Moffitt to aggressively pursue new ideas in the etiology, treatment and prevention of melanoma. The Moffitt Research Institute is comprised of approximately 140 Principal Investigators, 58 laboratories, and 306,000 square feet of research space. Outstanding Core Facilities are available to the investigators. The Cancer Center is comprised of a large ambulatory care facility, a 206-bed hospital, with a 36-bed blood and marrow transplant program, 12 state of the art operating suites, a 30 bed intensive care unit, a high volume screening program, and a basic science research facility. The Moffitt Cancer Center is affiliated with the University of South Florida. Primary and secondary University appointments are available, as applicable. Academic rank is commensurate with qualifications and experience. For inquiries about the position, contact Dr. Srikumar Chellappan at 813-745-6892 or Dr. Jeffrey Weber, Director, Donald A. Adam Comprehensive Melanoma Research Center, at 813-745-2007. Moffitt Cancer Center provides a tobacco-free work environment. It is an equal opportunity, affirmative action employer and a drug free workplace. http://www.newscientistjobs.com/jobs/job/sallie-rosen-kaplan-fellowship-for-women-in-basic-clinical-epidemiological-or-prevention-science-md-maryland-200564268.htmWed, 18 Nov 2009 18:12:48 +0000190076Sallie Rosen Kaplan Fellowship for Women in Basic, Clinical, Epidemiological or Prevention science National Cancer Institute Sallie Rosen Kaplan Fellowship for Women in Basic, Clinical, Epidemiological Or Prevention Science The Sallie Rosen Kaplan Fellowship for Women Scientists in Cancer Research is made possible by a generous bequest to the Foundation for NIH (FNIH). This is a competitive program for female postdoctoral fellows applying to train in any of the National Cancer Institute’s intramural research settings, including basic, clinical, epidemiological, and prevention science. The postdoctoral fellowship experience at the NCI can serve as a first postdoctoral training assignment, or offer more experienced postdoctoral scientists an opportunity to further their training in more advanced methods, to acquire new research capabilities, to make changes in the direction of their research, or to receive training in fundamental sciences and clinical disciplines for the purpose of enhancing the transfer of biotechnology to cancer clinical programs. Program duration is normally 2 to 5 years. Fellows will be supported by a Cancer Research Training Award (CRTA), with an augmented stipend in the first year provided by the FNIH. The CRTA Fellowship stipend range is $44,600 to $82,400 commensurate with level of experience. Standard self and family health insurance is provided and high option coverage is available. Candidates for the Sallie Rosen Kaplan Fellowship must be female, must possess a doctoral degree, and must have less than 5 years postdoctoral research experience. U.S. citizenship or U.S. permanent residency (green card) is required. Finalists for the Kaplan fellowship will be notified by March 2010 and winners announced by May 2010. To be eligible for the Sallie Rosen Kaplan Fellowship award, the starting date of any NCI fellowship must be no earlier than December 14, 2009. Applicants are required to apply online at http://www.training.nih.gov/apps/publicForms/postdoctoral/forms/adIndex.aspx by December 11, 2009. Additional information about the Kaplan Fellowship can be found at http://www.cancer.gov/researchandfunding/training/srk DHHS, NIH and NCI are Equal Opportunity Employers http://www.newscientistjobs.com/jobs/job/research-associate-cincinnati-oh-academic-oh-ohio-200580542.htmWed, 18 Nov 2009 15:44:27 +0000189822A Research Associate position is available immediately in the Department of Cancer and Cell Biology at the University of Cincinnati Genome Research Institute. The candidate selected for this position will examine therapeutic targeting of the mTOR pathway in a mouse model in which c-myc and E2F1 transgenes are expressed in the liver. Cohorts of c-myc/E2F1 mice will be treated either with RAD001, BEZ235, the two both drugs in combination or novel mTOR kinase competitive ATP inhibitors. Sera and tissue extracts will be analyzed by Western-immunoblotting for signaling pathway activation, proliferation and apoptosis. The concentrations of RAD001 or BEZ235 in serum and in tissues will be measured by high-performance liquid chromatography/mass spectrometry (HPLC/MS/MS) to determine whether mTOR kinase competitive ATP inhibitors are more efficacious as single agents in the treatment of hepatocellular carcinoma than BEZ235 alone or in combination with RAD001. All qualified candidates should submit a CV to position number 29UC5115 via the UC jobs website by clicking Apply Now below. http://www.newscientistjobs.com/jobs/job/expert-scientist-in-molecular-biology-belgium-200642529.htmWed, 18 Nov 2009 10:53:37 +0000189509GlaxoSmithKline Biologicals (GSK Biologicals) is one of the world’s leading vaccine manufacturers. The company is located in Rixensart (Belgium) and is the centre of all GlaxoSmithKline’s activities in the field of vaccine research, development and production. GSK Biologicals employs over 6 000 people in Belgium (over 9 000 worldwide), of whom more than 1 600 are passionate scientists devoted to discovering innovative vaccines and developing cost-effective and convenient combination products that contribute to the health and well-being of billions of people, in every generation around the world. Cancer remains a major cause of death and there remains a need for highly efficient and safer therapies. Therefore, GSK Biologicals is developing a novel approach to treat cancer based on Antigen-Specific Cancer Immunotherapeutic(s). ASCIs aim at educating the patients’ own immune system to fight the tumor. This process, which is common for pathogens such as viruses and bacteria, is intended to be harmless for the organism and therefore should elicit very few side-effects when compared to the other common anti-tumor treatments. ASCIs are investigational compounds. For its Antigen-Specific Cancer Immunotherapeutic(s) - ASCI(s) we are looking for a (m/f): Expert Scientist in Molecular Biology Mission: You are working for the clinical research, mainly in Phase I. Your main responsibility is to make sure the clinical samples are well processed and screened, in order to certify their relevance for possible inclusion in the clinical studies. As Expert Scientist, working in a team of 9 and leading a couple of technicians, you will have the following responsibilities: - you define the experimental strategy in line with projects priorities; - you define the scientific models and processes (mainly using Microarray, QPCR, SNP, Genomic DNA techniques); - you actively participate and hold responsibility in Project Team, Technical team as representative of your department ; - you provide input and recommendations to DAP (Disease Area Programmes) and Project Teams in terms of complexity, development time, process cost, … to ensure the best approach in technology/methodology; - you prepare and write reports on program achievements and laboratory activities; - you lead and implements the respect of the GxP/EHS/QA rules application in your team and lab ; - you lead and ensure project/ assay/ process transfer to other departments with a complete documentation (SOP/Qualification report/process transfer documentation). Profile: - you hold a PhD in Molecular Biology, a Master degree with a sound experience in a similar position is acceptable; - you have an experience in Molecular Biology applied to human cells; - mastering the microarray technique is a must. QPCR, SNP are assets; - you are English fluent, any other language is an asset; - experience in the oncology therapeutic area is an asset. Offer: - A challenging job within a highly innovative GSK Bio programme; - A contribution to high-tech research and development in the field of cancer - A growing, confident and ambitious business to be a part of driven by science, performance and the pride to ensure a healthier an happier life to patients How to apply? Apply online via the "Apply Now" button. Your application will be processed quickly and in confidence. habeas has exclusive right on this recruitment. Any candidate interested is invited to apply exclusively through the website www.habeas.be. http://www.newscientistjobs.com/jobs/job/toolmaker-medical-device-republic-of-ireland-200641939.htmTue, 17 Nov 2009 14:39:03 +0000194321Toolmaker – Medical Device - Dublin Requirements: o Toolmaking qualification plus time served with a toolmaker producing Injection Moulds. o Previous experience in an injection mold making / mold maintenance environment. o Good knowledge of milling, turning, grinding, sparking and fitting. o Ability to weld. o Good knowledge in mold maintenance and experience of supporting a high volume manufacturing environment. o Previous experience in the manufacture and/or repair/maintenance of the following mold types would be a distinct advantage: - Multi cavity moulds - Hot Runner moulds - Valve gated moulds -Stack moulds o Good understanding of the injection molding process. o Previous experience working on technically challenging applications would be an advantage (ie) medical, tight tolerance work. o Ability to interact with suppliers, customers and external toolmakers. o Knowledge of Hydraulics and Pneumatics would be an advantage. Essential Job Duties and Responsibilities: o Responsible for the maintenance of injection molds in the company and compiling standard specifications /procedures for each mold and monitoring all existing molds to standard specifications. o Responsible for, Jigs & Fixture manufacture, maintenance on the injection molding and ancillary equipment in conjunction with the machine supplier. o Works with the Production Group leaders in troubleshooting Mould problems. o Establishes relationships with the customers and suppliers in pursuit of continuous improvement and on-going business development. o Attends, schedules and facilitates internal meetings to help establish priorities and assign tasks. o Solves, in conjunction with the Quality department, customer related problems/issues as needed o In conjunction with approved toolmakers, research new processes and/or systems for maintenance/manufacture of moulds and implement new processes and systems as developed under the direction of the operations manager. o Instructs others, formally or informally, regarding manufacturing related skills or knowledge and assist in the training of employees on new processes or systems introduced to the company. o Coordinate the development of documentation in the toolmaking areas in line with ISO9001:2000 / ISO 13485 requirements and review of the systems with the Process Engineer/Group Leaders and the Quality department on a regular basis to ensure conformance to same. o Perform additional duties at the request of the direct supervisor. ************************************************************** For Immediate Consideration Please Apply Online Now If you would like further information before applying please contact: Brian Christensen BA(Mod.)MedChem on +353 1 685 4747 Your details will not be passed to a Third Party without your express Prior Consent. View our Privacy Policy *************************************************************** Life Science Recruitment | http://lifescience.ie http://www.newscientistjobs.com/jobs/job/post-doctoral-position-tawbi-laboratory-pa-pennsylvania-200638752.htmMon, 16 Nov 2009 17:07:48 +0000185735Post Doctoral Position- Tawbi Laboratory Applications are requested for a full time, postdoctoral position in the laboratory of Dr. Hussein Tawbi, Division of Hematology/Oncology, Hillman Cancer Center, University of Pittsburgh Cancer Institute. Dr. Tawbi’s laboratory studies the epigenetic regulation of DNA repair and mechanisms of post transcriptional regulation of genes associated with chemotherapy resistance. The successful applicant will be expected to have both the ability and motivation to be a major contributor to the lab’s research program. The project will involve the use of the following techniques: cell culture, RT-PCR, RNA expression, proteomics, immunohistochemistry and siRNA. These studies are primarily conducted in cell culture systems, in vivo, as well as tumor tissue, and require techniques in molecular biology and biochemistry. Candidates must hold a Ph.D in Cell Biology, or Molecular Biology. Experience with procedures on tissue culture and molecular biology methodologies are highly desirable. Excellent verbal and written communication skills are required. Dr. Hussein Tawbi M.D., M.Sc., Assistant Professor of Medicine http://www.newscientistjobs.com/jobs/job/faculty-positions-department-of-pharmacology-chemical-biology-pa-pennsylvania-200638760.htmMon, 16 Nov 2009 17:06:07 +0000185733Faculty Positions University of Pittsburgh School of Medicine Department of Pharmacology & Chemical Biology Applications are invited for tenure-stream Assistant Professor level faculty positions in the Department of Pharmacology & Chemical Biology. Candidates who have a Ph.D., M.D. or equivalent graduate degree are being recruited to expand a strong cadre of faculty. The University of Pittsburgh School of Medicine currently ranks 6th among NIH-funded academic medical centers, and the department is consistently one of the top NIH-funded Departments of Pharmacology. The School of Medicine and the department are executing an exciting vision for both the expansion and integration of basic research, clinical investigation and patient care missions. The department houses state-of-the-art facilities supporting microscopy, mass spectrometry, protein chemistry, gene expression profiling, genetic models of disease, receptor analysis, physiologic monitoring, physical chemistry, organic/combinatorial chemistry and high throughput drug discovery. Successful candidates must have excellent communications skills, develop an outstanding extramurally-supported research program and be committed to the graduate and medical teaching missions of the department. Salary and benefits are highly competitive, with excellent start-up investments available. While all strong applicants will be considered, the Department of Pharmacology & Chemical Biology has significant depth of expertise in cell and organ systems pharmacology, cardiovascular pharmacology, neuropharmacology, endocrinology, cell signaling, cancer biology, DNA damage/repair and drug discovery. Applicants should provide via e-mail a one-page statement of research objectives, curriculum vitae, and contact information for three references by December 31, 2009 to: Bruce A. Freeman, Ph.D. Irwin Fridovich/UPMC Professor Chair of Pharmacology & Chemical Biology University of Pittsburgh, School of Medicine W1340 Biomedical Science Tower Pittsburgh, PA 15261 E-mail: pharmdev@pitt.edu http://www.pharmacology.us/ The University of Pittsburgh is an Affirmative Action/Equal Opportunity Employer. http://www.newscientistjobs.com/jobs/job/postdoctoral-fellow-molecular-oncology-fl-florida-200634723.htmTue, 10 Nov 2009 22:05:06 +0000176266POSTDOCTORAL FELLOW – MOLECULAR ONCOLOGY Opportunities are available for Postdoctoral Research Fellows in the laboratory of Dr. Jiandong Chen at Moffitt Cancer Center. This is a post-graduate entry-level position in which the individual is responsible for assisting with research activities as well as conducting independent research projects when appropriate under limited supervision. We are looking for highly motivated individuals to study p53, MDM2, MDMX and SirT1 in an interdisciplinary environment in the Molecular Oncology Department. A PhD degree and strong background in molecular biology, biochemistry, or gene targeting in mice is required. Excellent verbal and written communication skills are required. The Moffitt Comprehensive Cancer Center is a modern facility on the University of South Florida Campus that conducts research on various aspects of Cancer Biology with emphasis on translational research. It is the third largest Cancer Center in the US based on patient volume. Research environment includes state of the art modern core facilities and pathogen-free modern animal facilities, access to clinical material, etc. Please visit the following link for more information on the group’s research: http://www.moffitt.org/Site.aspx?spid=39E20B90AE4045B792A62A46CA899D03&SearchType=Investigator, and visit www.moffitt.org/careers to apply online to Req ID # 4468 and send CV, cover letter and three references to Dr. Jiandong Chen at jiandong.chen@moffitt.org. http://www.newscientistjobs.com/jobs/job/nih-funded-postdoctoral-position-dept-of-radiation-oncology-pa-pennsylvania-200635416.htmTue, 10 Nov 2009 15:26:59 +0000176078NIH-funded Postdoctoral position is available immediately to study the molecular mechanisms of tumor cell adaptation to hypoxic and metabolic stress and the role of the Unfolded Protein Response in tumor progression (see http://www.xrt.upenn.edu/Koumenis.shtml). Highly motivated individuals with 0-3 yrs of postdoctoral experience, a Ph.D. in cancer biology or a related area are encouraged to apply. Preference will be given to candidates with experience with molecular biology techniques and animal tumor models. Competitive salary and a generous benefits package commensurate with experience will be provided. The University of Pennsylvania is an equal opportunity, affirmative action employer. Women and minority candidates are strongly encouraged to apply. Please submit curriculum vitae, a brief statement of research interests, and contact information for three references by e-mail to: Constantinos Koumenis, Ph.D., by clicking Apply Now below. http://www.newscientistjobs.com/jobs/job/qa-officer-central-200635327.htmTue, 10 Nov 2009 13:54:12 +0000175956QA Officer - 12 month maternity cover Salary: £23,000pa Job Ref: 16011 Established for over a decade our client, a leading pharmaceutical company focussing on the development of drugs for the treatment of CNS and oncology related illnesses, has a rare opportunity for a QA Officer to cover for a 12 month period of maternity. Reporting into the QA Manager the successful candidate will be responsible for reviewing documentation to cGMP and in-house specifications, maintaining & managing quality systems, supporting audits, deviation inspection and investigation to ensure compliance with regulations. Suitable candidates will have previous experience of auditing or documentation review within a quality management system, preferably within the pharmaceutical industry. The ability to focus on detailed documentation, demonstrating an accurate, detailed approach is crucial to this role. The ideal candidate will be degree qualified or equivalent with at least 1-2+ years Quality Assurance experience within the pharmaceutical industry working to GMP standards, experience of active ingredients or commercial manufacture would be advantageous. Based: Southern England http://www.newscientistjobs.com/jobs/job/post-doctoral-researcher-oh-ohio-200634609.htmMon, 09 Nov 2009 17:15:12 +0000174343A Postdoctoral Researcher position is available at the Comprehensive Cancer Center – James Cancer Hospital and Solove Research Institute at The Ohio State University. This position is expected to start in January 2010 under the direction of Dr. Qianben Wang, Assistant Professor, in the Department of Molecular and Cellular Biochemistry. The laboratory currently focuses on genome-wide transcriptional regulation by androgen receptor in prostate cancer (Wang et al. Cell, 2009; Wang et al. Mol Cell, 2007; Wang et al. Mol Cell, 2005). Applicants must have a Ph.D. (or equivalent) and preference will be given to those that have a solid background in molecular biology, genomics and cancer biology. Previous experience in Bioinformatics is a plus. To be considered for the position, CLICK APPLY NOW or: Send e-mail an updated cover letter, CV and three letters of reference to qianben.wang@osumc.edu with subject “postdoctoral researcher candidate”. EEO/AA Employer http://www.newscientistjobs.com/jobs/job/wnt-scientific-associate-developmental-molecular-pathways-ma-massachusetts-200633929.htmSun, 08 Nov 2009 09:12:13 +0000173293Scientist will be responsible for establishing mammalian cell-based assays for signal transduction systems with relevance to Novartis therapeutic areas, specifically the Wnt signaling pathway. The scientist will convert these assays into screens to identify compounds and genes with therapeutic potential for treating diseases ranging from cancer to osteoporosis. The scientist will use multiple techniques, including gene profiling, RNA interference, and chemical proteomics, to identify the mechanism of action of these agents. The scientist will be involved in designing, implementing and advancing scientific experiments, and should be able to provide critical analysis and interpretation of scientific data. The scientist will evaluate new technologies (e.g. high content screening and imaging) and recommend appropriate specialized laboratory equipment to develop novel assays. The scientist should be familiar with state of the art cell-based screening methods and the use of automated instrumentation. The scientist will also provide technical mentoring and expertise to other research staff in the group. The scientist will report results of studies and make recommendations to scientific leaders in a timely, thorough, organized and coherent manner. http://www.newscientistjobs.com/jobs/job/faculty-position-genome-stability-group-pa-pennsylvania-200633784.htmFri, 06 Nov 2009 22:29:07 +0000171978The University of Pittsburgh Cancer Institute (UPCI) and University of Pittsburgh has a strong program in Genome Stability and DNA Repair and seeks to recruit faculty at the junior and mid-career stage to develop outstanding research programs that bring approaches complementing our existing strengths. The current group consists of Chris Bakkenist, PhD (ATM signaling; DNA double-strand break repair); Laura Niedernhofer, PhD, MD (ERCC1; cross-link repair; mouse model of aging and cancer); Patty Opresko, PhD (DNA helicases; telomeric DNA damage, repair and replication); Vesna Rapic-Otrin, PhD (damage recognition by DDB; DDB-CUL4 E3 ligase and histone ubiquitination in chromatin); Robert Sobol, PhD (base excision repair; PARP & NAD+ signaling and metabolism; chemotherapeutic approaches in brain cancer); Ben Van Houten, PhD (structure-function of repair proteins; mitochondrial physiology); Yong Wan, PhD (ubiquitin-dependent proteolysis; cell cycle control; DNA damage responses). UPCI and University of Pittsburgh have world-class shared facilities including the Center for Biological Imaging (Simon Watkins, PhD) and the University of Pittsburgh Drug Discovery Institute (John Lazo, PhD). There are opportunities for extensive collaborations within the University of Pittsburgh Medical Center and Carnegie Mellon University, as well as opportunities for participation in related graduate programs. Interested applicants working on problems in all aspects of genome stability, including, polymerase fidelity, DNA double-strand break repair, structure-function studies of DNA repair enzymes and DNA damage responses, are encouraged to apply. We seek exceptional candidates using state-of-the-art biochemical and molecular biology tools working in an array of biological systems. We are also interested in candidates combining high throughput screens with bioinformatic approaches for the analysis of large data sets. Candidates with a track record of independent funding and publications in high impact journals will be given the highest consideration. Successful candidates will be expected to run a vibrant collaborative program supported by external funding. A competitive salary and research start-up package will be provided. The University of Pittsburgh School of Medicine is consistently among the top ten in NIH-funded medical schools in the U.S. and is located in one of America’s most livable cities. Positions will be coordinated with Departments in the University of Pittsburgh and are tenure track. To apply, please send your curriculum vitae, a one-page summary of your research plans, and three letters of recommendation to: Bennett Van Houten, PhD, UPCI Research Pavilion, Hillman Cancer Center Suite 2.6, 5117 Centre Avenue, Pittsburgh, PA 15213-1863, email: vanhoutenb@upmc.edu. Applications will be reviewed and evaluated on an ongoing basis. The University of Pittsburgh is an Affirmative Action, Equal Opportunity Employer. Faculty Position Genome Stability Group University of Pittsburgh Cancer Institute http://www.newscientistjobs.com/jobs/job/two-assistantassociatefull-professors-cancer-research-al-alabama-200633779.htmFri, 06 Nov 2009 21:55:55 +0000171974CANCER RESEARCH -- THE UNIVERSITY OF ALABAMA AT BIRMINGHAM The Department of Pathology, and the Comprehensive Cancer Center at the University of Alabama at Birmingham (UAB) are committed to building an active research and training program in cancer research. Two appointments for Assistant/Associate/Full Professor (PhD, MD/PhD, or DVM-tenure-earning and/or tenured faculty positions) with research interests in the broad areas of tumor pathobiology are available. We invite applications for candidates with an interest in the areas of tumor-stroma or tumor-bone interactions, angiogenesis, invasion/metastasis, cancer stem cells or cancer genetics. Successful candidates will have a demonstrated record of originality and productivity in research, existing or outstanding potential for consistent extramural funding, and an interest in graduate and medical education. UAB, which ranks in the top 25 in NIH funding, is a dynamic, collaborative research institution with state of the art facilities, outstanding graduate programs, and a commitment to post-doctoral education. Excellent lab space and competitive start-up packages are available. Interested candidates should submit a cover letter that includes research interest/experience, a curriculum vitae, and the names of three references to: Dr. Danny R. Welch, Professor, Division of Molecular and Cellular Pathology, Department of Pathology, University of Alabama at Birmingham, (please find full mailing address below by clicking View Contact Details) or email by clicking Apply Now. The University of Alabama is an Affirmative Action/Equal Opportunity Employer. Women and minority applicants are encouraged to apply. http://www.newscientistjobs.com/jobs/job/early-phase-project-management-international-oncology-studies-west-sussex-200633364.htmFri, 06 Nov 2009 16:01:26 +0000171559Early Phase Project Management - Surrey - International Oncology Studies RE-OPENED ROLE Are you a Senior CRA, Lead CRA or Project Manager who enjoys the pace and variety of Phase I studies? This is an excellent opportunity to work with a Pharma market leader where you will benefit from the opportunity to work on varied projects, within Phase I Oncology development. This top twenty Pharmaceutical Organisation and has a continually growing pipeline of exciting products. Role Overview Our client is currently looking to fill a vacancy for an Early Phase Project Manager - they are looking an organised, logical and enthusiastic candidate in order to support the planning and execution of trials. It is a challenging position that requires experience, knowledge and determination. You will be involved in the Oncology therapeutic area working on international studies. Duties and Responsibilities *Compound Planning: Represent exploratory operations on the clinical team, coordinate the exploratory portion of the PI clinical development strategy and develop initial exploratory designs, timelines and budget estimates. *Study Planning: Coordinate development of the protocol and amendments, and manage logistics of reviews, schedule and lead the study development process, collaborate with the clinical trials materials group, develop the monitoring plan, prepare and facilitate site start-up meetings(s) *Study Execution: Perform study specific site assessments, initiation, monitoring and close-out visits, negotiate budgets with investigators, coordinate all site supply logistics, report quality issues. *Documentation and Reporting: Ensure maintenance of databases at the trial and site level, prepare study reports, and be accountable for the completeness of the study file(s) and archiving. Essential Requirements and Experience: -Science degree with 3+ years industry experience (CRO, NHS, Pharma or Biotech) in the EU or USA -Strong problem-solving, planning and organizational skills -Excellent communication skills for effective interaction with global teams -Oncology experience -Position is fully office based in Surrey. Ability to travel to the site daily is essential. Desired Experience -Previous experience in Early Phase Clinical Research would be an advantage, especially at Project Management level. SCRAs with 3+ years seeking to progress will also be considered. - Ideally candidates will have a background in monitoring, however Project Managers from alternative background with Oncology will also be considered. If this is of interest please contact Holly Morgan holly@clinicalprofessionals.co.uk or on 0118 959 4990 Key Words: Phase I Junior Project Manager Project Manager Study Manager Trial Manager PhI PM jPM Pharmaceutical Biotechnology Clinical Research Clinical Trial Clinical Development Research and Development R&D Surrey Hampshire Berkshire Middlesex Kent Sussex Essex London South London West London UK Anywhere England (all) South East We are dedicated to the clinical research industry, offering candidates a unique service including our free \"Pipeline Watch\" career advisory consultation. To find out more call us on 0118 9594990 or email apply@clinicalprofessionals.co.uk http://www.newscientistjobs.com/jobs/job/clinical-operations-manager-oncology-partly-field-based-hertfordshire-200633358.htmFri, 06 Nov 2009 16:01:07 +0000171553Clinical Operations Manager (Oncology) - Hertfordshire / Partly Field Based - Permanent Do you hold 1 year + international Project Management experience? Are you looking for a company which is expanding and will offer long term career progression? This is an excellent chance to work for this global Pharmaceutical company in their large Oncology department. This a permanent role working on key Oncology studies Phase I-III. This role has a very international focus with trials worldwide, working with a dynamic team of Clinical Operations Managers and CRAs. You will be office based in Hertfordshire, although there is flexibility to work up to 2 days each week from home. Role Summary To co-ordinate all operational aspects of a clinical study within the Global Oncology development programme. You will lead the multi functional study team, co-ordinating activities and working closely with other team members from other functions such as data management, regulatory and pharmacovigilance. You will lead study teams at both a national and international level. Role Description * Work closely with the global study team members from different functional areas. * Ensure that study is conducted in accordance with ICH/GCP guidelines, local regulatory requirements and company SOPs and in accordance with agreed timelines. * Ensure quality of data are acceptable and suitable for regulatory submission * Maybe involved in training internal staff and CRO staff for the study if required. * Undertake co-monitoring visits with CROs when appropriate Qualifications and Skills A BSc or higher 1 years+ experience of independently leading a multi-national study either within Pharmaceutical Company or CRO in the UK or EU A full understanding of current EU and ICH/GCP guidelines. Used to handling vendors and have experience in reviewing study documents. Prior experience of Oncology or working on a complex protocol is highly desirable If this role is of interest please contact Holly Morgan on +44 (0) 118 959 4990 or e-mail holly@clinicalprofessionals.co.uk for more information. Key Words: Oncology Project Management Operational Management Study Management London North London Hertfordshire Cambridgeshire Bedfordshire Buckinghamshire Middlesex Relocatable UK Anywhere Pharmaceutical Biotechnology Research and Development R&D Global PM We are dedicated to the clinical research industry, offering candidates a unique service including our free \"Pipeline Watch\" career advisory consultation. To find out more call us on 0118 9594990 or email apply@clinicalprofessionals.co.uk