http://www.newscientistjobs.com/jobsNew Scientist Jobshttp://www.newscientistjobs.com/jobs/job/senior-programmer-software-architect-fl-florida-200599014.htmWed, 18 Nov 2009 14:51:43 +0000190844The John P. Hussman Institute for Human Genomics based at the University of Miami, Miller School of Medicine is at the forefront of genomics research, seeking to identify variation in the genes and gene networks that cause disease. Using cutting-edge technology and innovative approaches our goal is to discover the many genetic risk factors that affect susceptibility and prognosis for common, complex human disorders. The Informatics department, the John P. Hussman Institute for Human Genomics is looking for a looking for a qualified candidate to fill an immediate position as Software Architect. Reporting to the Application Development Manager, the individual will provide technical leadership for the development of systems across entire product lifecycle. Responsibilities include: leading design reviews and code reviews; evaluation of new technologies; and resolving complex technical issues to support our requirement to build robust, rapidly performing, scalable, maintainable, and cost-effective systems. Roles and Responsibilities • Help architect and develop applications for the clinical domain • Take a technical leadership role and help shape the "big picture" on projects • Collaborate on architecture and design decisions with the team of analysts and developers • Define architecture for new products and features. • Review designs, code, and test plans. • Provide technical leadership to the engineering team for the entire lifecycle of the project. • Rapid prototyping / proof of concept for new ideas. • Evaluate vendor technologies and support the vendor selection process. • Resolve technical issues. • Provide technical mentoring of other engineers. • Troubleshooting. • Performance tuning. • Assist in the design and integrate applications and technologies • Provide analysis and report on new, innovative software technologies. • Prepare and review necessary product-related documentation. Ideal Skills • Sound knowledge of Java EE and best practices • Knowledge of OO design patterns, refactoring and unit testing • Knowledge of Agile Methodologies such as Scrum is preferred • Knowledge of database design in Oracle and best practices • Knowledge of using Access Control List technologies • proven ability to create and architect solutions that are scalable, maintainable, reliable, and perform well • Familiarity with EDI standards. Familiarity with HL7 and RIM model. • Experience with ESB technologies preferred. • Full life-cycle development experience, including large-scale applications • Analytical skills, and an ability to effectively work cross-functionally • Results-oriented, team-oriented and exceptional hands-on analytical and problem-solving skills. The successful applicant will be joining an informatics team that has significant expertise in using informatics to address and solve problems in clinical genomics. This is an exciting, wide-ranging opportunity to become part of a team involved in ground-breaking medical research. The University of Miami, Miller School of Medicine is proud to offer those who lead with us competitive compensation and benefits. The University of Miami is an Equal Opportunity/Affirmative Action Employer. Please visit our website: www.mihg.org JOB REQUIREMENTS: Qualifications • BS in Computer Science or equivalent, advanced degree a plus • 6+ years design, development, and deployment of software development projects • Experience as an official “Lead Architect" or “Chief Architect" preferred • Experience in a leadership and mentoring would be a plus • 6+ years in Java EE or analogous server side java frameworks and middle ware technologies • Experience with LDAP and other access control technologies preferred • Extensive experience working with relational database management systems • Healthcare and Clinical domain knowledge preferred Discover all this and countless opportunities that reward your talent. The University of Miami, Miller School of Medicine is proud to offer those who lead with us competitive salaries, medical and dental benefits, tuition remission, vacation, university paid holidays and much more. The University of Miami is an Equal Opportunity/Affirmative Action Employer. To apply for this position, please click apply now below http://www.newscientistjobs.com/jobs/job/software-engineer-ii-ma-massachusetts-200641965.htmTue, 17 Nov 2009 19:58:41 +0000189446Bioinformatics Software Engineer (Visual C++) : Boston, USA We cordially invite applications for a one-year Bioinformatics Software Engineer position in computational biology and bioinformatics. The position may be extended contingent on obtaining further funding. The candidate will implement the new microarray and sequencing analysis and visualization functions in the dChip software (www.dchip.org), maintain the source code, and support users. The candidate should be proficient in Visual C++ and Windows graphical user interface, and be familiar with Python and R. The candidate should also have a working knowledge of molecular biology and genomics data analysis. Qualifications: 1) An MS or Ph.D. degree in biostatistics, computer science, or related fields; 2) Familiarity with molecular biology and genomics; 3) Strong programming skills (C++, Python, R) Please visit our website to apply by clicking Apply Now below. http://www.newscientistjobs.com/jobs/job/assistant-professor-and-associate-professor-positions-ma-massachusetts-200641020.htmMon, 16 Nov 2009 19:28:37 +0000186900ASSISTANT PROFESSOR AND ASSOCIATE PROFESSOR POSITIONS MASSACHUSETTS GENERAL HOSPITAL HARVARD MEDICAL SCHOOL DEPARTMENT OF DERMATOLOGY Positions for Assistant Professor and Associate Professor, are available at the Cutaneous Biology Research Center of MGH/Harvard Medical School/Department of Dermatology. Applicants must have a Ph.D. and/or M.D. degree, and a strong interest relevant to cutaneous biology, including but not limited to immunology, chemical biology, epigenetics and clinically oriented skin research. Current faculty members investigate inductive signaling, transcriptional regulation, apoptosis, angiogenesis, carcinogenesis, extracellular matrix function, and appendage development in vertebrate systems. Excellent core facilities and generous start-up funds are available. Interested candidate should send, via email only, curriculum vitae, brief statement of research directions, names, full addresses and emails of three references no later than March 1, 2010. TO COMPLETE THIS APPLICATION CLICK APPLY NOW BELOW The MGH/Harvard Cutaneous Biology Research Center is a committed Equal Opportunity/Affirmative Action Employer. Minorities, women, handicapped, and veterans are encouraged to apply. http://www.newscientistjobs.com/jobs/job/senior-technical-officer-combined-with-research-studentship-bioinformatics-and-computational-biology-hertfordshire-200640319.htmMon, 16 Nov 2009 11:13:27 +00001861432 year fixed term contract This post is a technical post combined with a research studentship opportunity. We are looking for an experienced bioinformatics technician who will provide specialist technical support for our bioinformatics and computational biology teaching and research. Your responsibilities will also include direct assistance for students and researchers. Adaptable and eager to learn you will be self-motivated and an excellent communicator. You will be educated to HND/ Degree/ NVQ level 4 in a science subject or have equivalent experience. You will have proven experience working in a bioninformatics/computational environment, which is not likely to have been attained in less than 3 years. This post is combined with a research studentship in one of the following areas: investigating the role of human intronless genes and the relationship to protein turnover based on our intronless gene database (in collaboration with the School of Computer Science), or investigations of biomedically relevant protein structures with bioinformatics and molecular modeling. You will be expected to work half time (mornings only, five days per week) as a member of technical staff and the other half as a research student. For informal enquiries please contact Jenny Harman, Technical Manager, on 01707 285184. Closing Date: 30 November 2009 Quote Reference: HH9068 The University offers a range of benefits including a final salary pension scheme, professional development, family friendly policies, child care vouchers, waiving of course fees for the children of staff at UH, discounted memberships at the Hertfordshire Sports Village and generous annual leave. Apply online by clicking the Apply Now button or request an application pack from Human Resources by calling the number listed within the 'View Contact Details' section below, quoting the appropriate reference number. http://www.newscientistjobs.com/jobs/job/phd-position-in-computational-evolutionary-genomics-switzerland-200638500.htmFri, 13 Nov 2009 16:18:49 +0000183529Job description We are looking for a highly motivated and innovative PhD student candidate (~4 years) to explore the wealth of genomic data from evolutionary perspective using bioinformatics approaches. Our group has a broad range of interests related to the functional evolution of genomes, and actively contributes to international genome analysis consortiums. The specific project will be developed together with the candidate. The project will be supervised by Prof. E. Zdobnov at the Department of Genetic Medicine and Development of the University of Geneva Medical School. We are also part of the renowned Swiss Institute of Bioinformatics, and offer a stimulating research environment with excellent facilities. The international city of Geneva, described as 'the smallest of the large capitals', offers a vibrant city life within easy reach of the picturesque lake and stunning Alps. Closing date for applications: 15 November 2009. Profile requirements The ideal candidate should have a strong background in bioinformatics, including programming skills (or the willingness and drive to acquire them), and a good understanding of molecular biology (preferably with some experience/background in molecular evolution). A Diploma or MSc degree in Biology or Bioinformatics, practical experience in the Unix environment, and fluency in English are required. Please send your CV, statement of research interest, and names and contact details of at least two referees by e-mail to Evgeny.Zdobnov@isb-sib.ch http://www.newscientistjobs.com/jobs/job/molecular-oncology-data-analyst-at-swiss-institute-of-bioinformatics-lausanne-200638494.htmFri, 13 Nov 2009 16:18:43 +0000183525Job description We are undertaking a project to characterize and biologically understand molecular heterogeneity of a specific cancer types by combining studies with multiple types of genomics and epigenomics technologies, as well as combining public and proprietary data To complete the data analysis team we seek a versatile highly motivated and well-trained postdoctoral researcher with an interest in biomolecular data mining with high throughput data. In particular, the scientist will explore connections between the different molecular profiles (mRNA and miRNA expression, DNA methylation, gene mutation and CNV) and interpret the data in the contest of biochemical signaling pathways and their relevance to tumor growth and progression. Job tasks -Integration of molecular profile data with prior biological knowledge (biological function and pathway databases, role in diseases) -Biological interpretation to make sense out of results from data analyses of large bodies of complex data -Interrogate data with plots, data mining techniques and statistical analysis in collaboration with statisticians and molecular biologists to find patterns, generate hypothesis and propose ways to validate them -Secondary responsibilities: Contribute to bioinformatics data analysis -participate in meetings -write documentation and reports Profile requirements -PhD in biochemistry, bioinformatics or equivalent -excellent knowledge of cancer biology and biochemistry -enthusiastic interest for research at the crossroads of experimental and computation methods and of basis and clinical research -excellent interpersonal skills for working within a team of biologists and programmers. -high-level understanding of bioinformatics and statistics methods -good English speaking and writing skills Preferences -Preference will be given to candidates who have excellent written and oral communication skills, an in depth understanding of the biological questions, and are good team players. -experience with genomic databases and with software tools for exploration of biochemical pathway activity (Partek, Ingenuity/MetaCore, Genome Studio or the like) -experience in the analysis of high-throughput genomic / genetic data, particularly the interpretation of molecular profile or genotype data -knowledge of biological pathways-regulation principles and mechanisms -sound background in Computer Science, Engineering, Mathematics, Physics, Bioinformatics or related quantitative science. Salary & Benefits Salary: 75 - 100 kCHF (50 - 70 k€) per year, depending on experience and qualifications. SIB offers an attractive social security system. Additional information SIB is a not-for-profit organization that offers excellent bioinformatics infrastructure and a stimulating research environment. In addition to powerful computer hardware, the SIB branches maintain a large collection of molecular biology databases and software packages. The scientist will be working in a multidisciplinary team with great expertise in applications of bioinformatics and biostatistics to translational research. The project is in collaboration with the biomarker discovery unit of a major pharmaceutical company. The position will open opportunities for careers in basic or applied research in academia or in the private sector. Please send your application to The application should include a cover letter, with summary of motivation, research interests and past accomplishments; curriculum vitae including description of skills and experiences; names and email addresses of at least three referees. Please also indicate if you are already authorized to work in Switzerland or the EU (visa). Applications will be considered as soon as possible. They and should be sent with Subject line: “Application Biomarkers BCF-October2009” to: Job contact person Dr. Mauro Delorenzi Head BCF Swiss Institute of Bioinformatics (SIB) Quartier Sorge - Batiment Genopode CH-1015 Lausanne Mauro.delorenzi@isb-sib.ch http://bcf.isb-sib.ch Lausanne [www.lausanne.ch/] is a beautiful lakeside city in Switzerland, in a French speaking area close to the Alps. http://www.newscientistjobs.com/jobs/job/web-developer-cambridge-uk-bioinformatics-institute-united-kingdom-200638827.htmFri, 13 Nov 2009 12:42:10 +0000183079We are looking for a web developer to work in the Ensembl Genomes group at the European Bioinformatics Institute (EBI). The web developer will be responsible for the maintenance and development of Ensembl Genomes web code. S/he will be working in collaboration with the Wellcome Trust Sanger Institute on the development of Ensembl web code. The tasks will include: • working on preparing the web code for new releases of Ensembl Genomes; • development of new features in Ensembl Genomes web code; • development and application of testing and monitoring framework; • attending meetings with external services, systems and Ensembl web developers at Sanger; • bug fixing; and • providing support for external collaborators needing to run Ensembl systems. The web developer will report to the Ensembl Genomes Web Team Leader. S/he will work in a small web-focused team that takes input from a larger group of general developers, and which works in close collaboration with a number of other groups (the EBI systems and external services teams, and Ensembl developers at the Wellcome Trust Sanger Institute). The successful candidate should have a degree in computing, mathematical or biological sciences and will have had a minimum of either three years professional programming experience, or one years experience developing web applications in Perl. Experience of working in genomic biology or bioinformatics is desirable but not essential. The successful candidate will be an expert in Perl, and knowledge of Apache, mod_perl, relational database management systems, Ensembl and testing frameworks would be highly beneficial. The web developer needs good team-working skills, a flexible mindset, an ability to manage time in the face of multiple demands and a commitment to the delivery of a high-quality public service. Excellent communication and interpersonal skills are essential. An initial contract of 3 years will be offered to the successful candidate. This can be renewed, depending on circumstances at the time of review. For further information please visit http://www.embl.org/ and http://www.ebi.ac.uk/. EMBL is an inclusive, equal opportunity employer offering attractive conditions and benefits appropriate to an international research organisation. Please note that special visa requirements apply to persons from countries outside the EU coming to work at EMBL-EBI in the UK. This period of work will not count as qualifying time in the Highly Skilled Migrant Programme. To apply, please email a cover letter, CV (in English) and contact information of three professional references quoting ref. no. NS/09/102/EBI in the subject line, to: applications@ebi.ac.uk. http://www.newscientistjobs.com/jobs/job/bioinformatician-cambridge-uk-bioinformatics-institute-united-kingdom-200638772.htmFri, 13 Nov 2009 12:41:13 +0000183075We are looking for a bioinformatician who will perform data integration and analysis for the VectorBase project in the Ensembl Genomes group at the European Bioinformatics Institute (EBI). The VectorBase project is a collaborative NIH-funded project with 5 external partners. The bioinformatician will be expected to work with our partners to ensure the optimal development of the resource. The tasks will include: • Data integration and analysis for the VectorBase project, including gene prediction, comparative analysis, cross reference assignment etc. • Collaboration with partners within the VectorBase consortium to schedule and build releases (through attendance at phone conferences, meetings etc); • Collaboration with external groups working on species of interest to VectorBase; • Working with the rest of the Ensembl Genomes team to facilitate the development of resources for all non-vertebrate genomes; The post-holder will report to the Ensembl Metazoa Coordinator. The EBI is part of the European Molecular Biology Laboratory (EMBL) to provide cutting-edge research, service and training in the field of bioinformatics. It is located on the Wellcome Trust Genome Campus at Hinxton near Cambridge in the UK. The successful candidate should have a degree in computer science or bioinformatics; or a degree in biological sciences, and a post-graduate qualification in computer science or bioinformatics. S/he should have had a minimum of two years professional programming experience (or a bioinformatics based PhD). Experience of working in genomic biology or bioinformatics is highly desirable but not essential for this position. An expert knowledge of some aspect of metazoan biology is advantageous but not required. The bioinformatician should be an expert in the Perl programming language, and be highly familiar with relational databases. Experience of handling large data sets is a prerequisite, knowledge of other programming languages is desirable but not essential. Prior knowledge of Ensembl, or genome annotation, is advantageous but not required. The bioinformatician will work as one of a group of developers working on the EBI contribution to VectorBase, a database maintained by an international consortium. The bioinforamtician should display a good ability to manage their own workload, balance priorities and schedule work both internally and with our external collaborators. Diligence is a desirable trait and an interest in genome annotation is essential. Excellent communication and interpersonal skills are required. An initial contract of 3 years will be offered to the successful candidate. This can be renewed, depending on circumstances at the time of review. For further information please visit http://www.embl.org/ and http://www.ebi.ac.uk/. EMBL is an inclusive, equal opportunity employer offering attractive conditions and benefits appropriate to an international research organisation. Please note that special visa requirements apply to persons from countries outside the EU coming to work at EMBL-EBI in the UK. This period of work will not count as qualifying time in the Highly Skilled Migrant Programme. To apply, please email a cover letter, CV (in English) and contact information of three professional references quoting ref. no. NS/09/101/EBI in the subject line, to: applications@ebi.ac.uk. No agencies. http://www.newscientistjobs.com/jobs/job/computational-biologist-data-analyst-microarray-east-anglia-200638676.htmThu, 12 Nov 2009 17:48:46 +0000181816A fantastic opportunity is available for a senior computational biologist with a proven background in statistical data analysis. Joining an award winning team, the successful candidate will be responsible for applying statistical data analysis techniques to new cutting edge genetic research projects. Key responsibilities will also include writing publications for appropriate scientific journals, collaborating with other bioinformatics research organisations throughout the UK and presenting your research findings at appropriate scientific meetings. The ideal candidate will be educated to a PhD level in Bioinformatics / Computational Biology with a strong grounding in statistical research and development. Previous exposure to microarray data analysis and/or large scale resequencing data would be highly advantageous. To succeed in this role it is essential that you are confident in the analysis of genome-wide data and have prior knowledge of sequence data. Rewards include a generous salary and benefits scheme including healthcare, contributory pension and good opportunities for learning and development. This is a once in a life time chance to put your experience to the test and play a major part in influencing projects alongside some of the UK's leading scientists. For more information on this role contact Kieron McDaid at Paramount Recruitment on 01216163462 Keywords: Microarray, Bioinformatics, Machine Learning, Statistics, R, Genetics Paramount Recruitment Limited provides services as an agency and an employment business. We regularly have similar roles in this area. Please see our website for details or send your CV in to us to find out the latest opportunities. http://www.newscientistjobs.com/jobs/job/senior-director-clinical-data-management-nj-new-jersey-200635976.htmWed, 11 Nov 2009 14:41:53 +0000178681The major responsibility of this position includes the strategic, operational and administrative oversight of the Consumer Healthcare (CH) Clinical Data Management. Other key responsibilities of this position include system owner of the clinical data management system, business continuity plan development and ownership, , coordination of clinical data input from several sources, liaison with Clinical Operations and the leadership/participation of process and technical improvement initiatives, and liaise with Business Systems and Processes on disaster recovery approach. As the designated system owner, support/ensure development and implementation of quality technology systems in accordance with IS Standard Operating Procedures/Policies and regulatory requirements. Work closely with Business Systems and Processes and CH Compliance management in the areas of technical and process design, validation and change management. Departmental Operations/Administration: Oversight of the operational/administrative activities for the Clinical Data Management team and prioritization of projects. Interface and resolve daily needs and expectations. This includes but is not limited too; - Manage / oversight of Clinical Data Management staff and contractors - Review and approval of service requests - Allocation of office space and equipment - Assure authorized/trained staff have access to required systems - Assure security checks and building access - Assure Clinical Data Management staff and contractors are fully trained - Clinical Data Management Team Representative on Clinical Project Teams - Serves as principal representative to clinical project teams in protocol planning and review of activities - Assures proper data workflow processes are in place - Participates in review and selection of CROs involved in data generation of clinical data, laboratory data or other study related data - Coordinates data entry, database design, verification and validation activities within data management group and among various sources of clinical data Business Continuity Planning: - Plays a key role in Business Continuity planning activities; - Administer, maintain, and assure periodic review/exercises of the business continuity plans - Liaise with the Business Systems and Processes team to ensure disaster recovery plans align with the business continuity plans, and are reviewed and exercised per the SOP requirements. - Oversight of the Consumer Heath Clinical Data Management business continuity plans. Budget and Finance: - Responsible for preparing annual budget requirements for Clinical Data Management - Builds, maintains and tracks budget allocations - Ensure global expenditures are effectively managed - Prepare/maintain purchase orders and review/approve monthly invoices for vendors and contractors Special Project Management: - Provide leadership and participation on special projects and/or cross-functional teams involving process and technology improvements; e.g. Thermacare Clinical Database Project Submission Ready Components (SRC) Qualifications: - Bachelor’s degree in life science, computer science or related field. MS, PhD or PharmD preferred. - 10 years total work experience in Clinical Data Management - 5 years experience in the pharmaceutical/ consumer healthcare industry - 5 years in management/supervision - 3-5 years in project management - Ability to handle multiple projects simultaneously - Excellent interpersonal and collaborative skills - Excellent organization and follow-up skills - Demonstrated problem solving and analytical skills Throughout our 153 years, a legacy of caring for others has been at the heart of everything we do at Pfizer. This commitment is no less important when it comes to our employees. Pfizer wants to ensure that employees have resources to help them develop and succeed both in their careers and personal lives. One way we can achieve this is through our comprehensive benefits program, which offers employees and their eligible dependents the variety and flexibility to help address their needs at different stages in life. Pfizer Inc: Working together for a healthier world™ Founded in 1849, Pfizer is the world's premier biopharmaceutical company taking new approaches to better health. We discover, develop, manufacture and deliver quality, safe and effective prescription medicines to treat and help prevent disease for both people and animals. We also partner with healthcare providers, governments and local communities around the world to expand access to our medicines and to provide better quality health care and health system support. At Pfizer, colleagues in more than 90 countries work every day to help people stay happier and healthier longer and to reduce the human and economic burden of disease worldwide. Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as employment eligibility verification requirements of the Immigration and Nationality Act. All applicants must have authorization to work for Pfizer in the U.S. HOW TO APPLY: Please copy and paste the following URL into your browser address bar: http://posttrak.arbita.net/cgi-bin/PostTrak.cgi?RefCode=R3832125807948 http://www.newscientistjobs.com/jobs/job/postdoctoral-fellow-computational-genomics-team-78-ref-80464-united-kingdom-200635559.htmTue, 10 Nov 2009 17:06:56 +0000177250Salary range £28000 to £34433 dependent on experience. Closing date is: 29th November 2009 The Wellcome Trust Sanger Institute is a world leader in genomic research, with an expanding scientific programme dedicated to understanding gene function in health & disease. A post-doctoral bioinformatician is sought for a cutting edge research programme in the Cancer Genome Project. The Postdoctoral Fellow will focus on the application of new sequencing technologies to identify genetic variants in cancer genomes, including the development of novel algorithms for sequence analysis and mutation calling, informatic analysis of mutational patterns and cancer gene identification. Essential Skills • PhD which includes a substantial component in bioinformatics or computer science (or equivalent experience). • Experience in the analysis and manipulation of large datasets, such as accessing data via MySQL or commonly used bioinformatics APIs. • Proven record of writing analysis programs and scripts to rapidly investigate scientific questions • Ability to work independently to carry out data analysis • Excellent attention to detail and good communication skills Ideal Skills • Interest/previous experience in genomic analysis Other information The Wellcome Trust Sanger Institute Sanger Institute operates at the forefront of genomics, sequencing and analyses of a wide range of genomes from single cell pathogens to higher vertebrates, with an emphasis on genomes relevant to human medicine and welfare. The Cancer Genome Project at the Institute has led the way in the systematic analysis of cancer genomes by using the human genome sequence and high throughput mutation detection techniques to identify somatically acquired sequence variants/mutations and hence identify genes critical in the development of human cancers. The ideal candidate would be from a programming background interested in applying their knowledge in the field of genomics. They will be able to work independently, enjoy collaborating with different teams, assimilate tasks easily and generate scripts quickly to analyse genomic data whilst supporting the research of the team and producing publications. Postdoctoral Fellows are typically in their first or second postdoctoral position as part of a period of early career research training. This a fixed-term contract for 3 years. Benefits The Institute has excellent purpose built facilities on the Genome Campus, Hinxton on the outskirts of Cambridge. We offer a comprehensive range of benefits including a final salary pension scheme and excellent on-site facilities. Further details can be found on our website https://jobs.sanger.ac.uk, To submit your CV and apply for this job please go to https://jobs.sanger.ac.uk, to register and apply on line. http://www.newscientistjobs.com/jobs/job/postdoctoral-research-project-concerted-bioinformatics-approach-to-uncover-the-function-of-human-proteins-lausanne-200634931.htmTue, 10 Nov 2009 09:38:14 +0000176560About 5'000 of the estimated 20'000 human proteins are lacking experimental evidence for their function. This is clearly a major issue in any systems biology approach, as it seriously impairs the modeling of biological processes. The goal of this research project is to evaluate the potential of data mining approaches to discover clues about the possible function of yet uncharacterized human proteins. By making the best use both of available knowledge resources and repositories and the predictive power of state-of-the-art bioinformatics tools, our ambition is to supply suggestions for possible wet-lab experiments which would be carried out to reveal the function of the targeted proteins. SystemX.ch, the Swiss initiative in Systems Biology is supporting this interdisciplinary pilot project (IPP) because it explores a new research direction which, while being 'high-risk', is critical to Systems Biology. The successful applicant will be working in a multidisciplinary team which has great strength in the application of bioinformatics and biostatistics to biological and medical research and which has created world known resources such as Swiss-Prot, PROSITE and the ExPASy web site. Profile requirements - PhD in computational biology, bioinformatics or computer science; - Strong background in statistics and/or machine learning techniques; - Experience in the development of new numerical methods; - Good understanding and enthusiastic interest for biology Additional information SIB is a not-for-profit organization that offers an excellent bioinformatics infrastructure and a stimulating research environment. The project is a collaboration between two SIB groups: CALIPHO, a new group headed by Amos Bairoch -who created and developed Swiss-Prot from 1986 to 2009 -and by Lydie Lane. CALIPHO is an interdisciplinary team composed of biocurators, bioinformaticians and experimentalists, whose aim is to use a variety of methodologies to help uncover the function of uncharacterized human proteins and Vital-IT, headed by Ioannis Xenarios which provides a high-performance computing environment to support the research work of its partners in areas ranging from sequence analysis through molecular modeling to image processing. Duration: One year possibly renewable with new fundings. http://www.newscientistjobs.com/jobs/job/post-doctoral-researcher-oh-ohio-200634609.htmMon, 09 Nov 2009 17:15:12 +0000175416A Postdoctoral Researcher position is available at the Comprehensive Cancer Center – James Cancer Hospital and Solove Research Institute at The Ohio State University. This position is expected to start in January 2010 under the direction of Dr. Qianben Wang, Assistant Professor, in the Department of Molecular and Cellular Biochemistry. The laboratory currently focuses on genome-wide transcriptional regulation by androgen receptor in prostate cancer (Wang et al. Cell, 2009; Wang et al. Mol Cell, 2007; Wang et al. Mol Cell, 2005). Applicants must have a Ph.D. (or equivalent) and preference will be given to those that have a solid background in molecular biology, genomics and cancer biology. Previous experience in Bioinformatics is a plus. To be considered for the position, CLICK APPLY NOW or: Send e-mail an updated cover letter, CV and three letters of reference to qianben.wang@osumc.edu with subject “postdoctoral researcher candidate”. EEO/AA Employer http://www.newscientistjobs.com/jobs/job/bioinformaticsgenomics-tenure-track-position-wv-west-virginia-200633783.htmFri, 06 Nov 2009 22:25:56 +0000175464Bioinformatics/Genomics: West Virginia University invites applications for a tenure-track position at the Assistant Professor level in the Department of Biology beginning August 2010. We are seeking applications from individuals with a broad biology background and strong computational skills to develop an externally funded, independent research program. Successful applicants may participate in WVU’s Computational Biology initiative (http://www.as.wvu.edu/~sdifazio/compbio.pdf), and existing programs in genomics, molecular biology, environmental biology, physiology, and/or neurobiology at West Virginia University. We especially seek individuals who apply computational methods in the field of functional genomics. Excellent written and oral communication/teaching skills and a demonstrated potential to secure external funding are required. PhD in hand is expected by the time of the appointment, with preference given to candidates with postdoctoral experience, a record of scholarly publications, and evidence of effective teaching at the undergraduate and graduate levels. Qualified applicants should submit statements of research qualifications and teaching philosophy, curriculum vitae, representative publications, and arrange for three letters of reference to be sent separately to the address below. Review of applications will commence on December 6 and continue until the position is filled. Applications should be sent electronically by clicking Apply Now or by mail to Stephen DiFazio, Search Committee Chair, Department of Biology, (for full address please click View Contact Details below). For more information: http://www.as.wvu.edu/biology/faculty/positions.htm or phone: (304) 293-5201 ext. 31512. West Virginia University is an Equal Opportunity, Affirmative Action Employer and does not discriminate on the basis of race, color, religion, sex, age, marital status, disability, veteran status, national origin, or sexual orientation. http://www.newscientistjobs.com/jobs/job/programmer-clinical-application-support-engineer-fl-florida-200633776.htmFri, 06 Nov 2009 21:04:35 +0000173043We strive to deliver the best – in patient care, research, and education. Experience amazing opportunities and outstanding rewards with the University of Miami, Miller School of Medicine. The John P. Hussman Institute for Human Genomics based at the University of Miami, Miller School of Medicine is at the forefront of genomics research, seeking to identify variation in the genes and gene networks that cause disease. Using cutting-edge technology and innovative approaches our goal is to discover the many genetic risk factors that affect susceptibility and prognosis for common, complex human disorders. The successful applicant will be responsible for creating complex CRFs (Clinical Research Forms) using the in-house CRF engine to automate the processes required to translate data dictionaries to CRFs for a production environment. The successful candidate would need to use java and java script to include edit-checks, range-checks and cross-form checks for clinical research databases. The successful applicant would need to: * Work with java software engineers to provide an in-house Clinical Research Form generating capability * Provide ongoing support for the deployed forms * Review existing data collection forms and data entry screens, identify and correlate variables between Data Collection Forms and databases * Gather requirements and create data dictionaries (code-books) for new CRFs * Maintain data dictionaries including creating pseudo code for edit-checks, range-checks and cross-form checks for clinical research databases * Assist in testing of new applications and software. QA applications screens and modules. Document test results and issues The candidate should be self-motivated and have experience working independently as well as in a team environment with software engineers. The candidate should have excellent project and time-management skills to prioritize and accomplish tasks. JOB REQUIREMENTS: Bachelors Degree in Computer Science/Biological Sciences/ Engineering or related field is preferred with a passion for actively participating in delivering innovative achievements for next-generation clinical research computer systems. One year minimum of related experience is required.The candidate should possess experience with HTML, CSS and JavaScript. The candidate will need to be proficient with translating requirements to responsive user interfaces in a “release-early, release-often” development environment.Any appropriate combination of education, certifications and/or relevant work experience will be considered. Discover all this and countless opportunities that reward your talent. The University of Miami, Miller School of Medicine is proud to offer those who lead with us competitive salaries, medical and dental benefits, tuition remission, vacation, university paid holidays and much more. To Apply Click APPLY NOW BELOW The University of Miami is an Equal Opportunity/Affirmative Action Employer http://www.newscientistjobs.com/jobs/job/bioinformatics-scientist-dna-sequencing-east-anglia-east-anglia-200633706.htmFri, 06 Nov 2009 17:47:20 +0000173008Bioinformatics Scientist DNA Sequencing East Anglia A new opportunity has become available for a bioinformatician/research scientist to spear head a new team developing cutting edge genomic analysis topics. In particular, I am on the lookout for a computational biologist with a proven background in genomics or genetics research and high-throughput DNA sequencing. The successful applicant will be working in close collaboration with a variety scientific research groups both in the UK and Europe. The ideal candidate will be educated to a Msc level in Bioinformatics, Genetics or Computer Science. You will be confident in your ability of leading a multi disciplinary team of scientists and computational biologists and eager to stay abreast with latest developments and techniques within the bioinformatics community. Previous exposure to microarray data analysis and large scale re-sequencing data would be highly advantageous. Rewards include a generous salary and company benefits scheme along with the opportunity to push forward your career and play a major part in influencing projects within a market leading organisation. For more information on this role contact Kieron McDaid at Paramount Recruitment on 01216163462 Keywords: Gene Expression, Microarray, Bioinformatics, DNA Sequencing, Computational Biology Paramount Recruitment Limited provides services as an agency and an employment business. We regularly have similar roles in this area. Please see our website for details or send your CV in to us to find out the latest opportunities. http://www.newscientistjobs.com/jobs/job/computational-biologist-cambridge-uk-bionformatics-institute-united-kingdom-200633099.htmFri, 06 Nov 2009 16:44:31 +0000172802An experienced computational biologist is sought to join a Wellcome Trust funded collaboration between laboratories from the European Bioinformatics Institute (Janet Thornton) and University College London (Linda Partridge, Dominic Withers, David Gems). The goals of the research programme are to understand how single gene mutations in the insulin/lgf-like signalling pathway extend healthy lifespan and ameliorate ageing-related disease. A variety of approaches, including functional genomic, are used and experimental systems include nemotode worms, fruit flies and mice. The computational biologist will have responsibility for guiding a small team of bioinformaticians at the EBI in their activities to analyse microarray and other high-throughput data being generated by the UCL-based teams. The appointee will foster a research program to develop novel computational approaches for analysing microarray and deep sequencing data. As the research program of the consortium moves towards use of next-generation sequencing technologies, s/he will be expected to guide the adoption of these technologies by providing input into experimental design and devising strategies for downstream data analysis. The EBI, located on the Wellcome Trust Genome Campus near Cambridge in the UK, is a global centre for biological data, hosting the very large sequence, structure and expression data resources in Europe as well as eight dedicated research groups. It provides an excellent research environment including access to outstanding students and post-doctoral scientists from around Europe, and computational facilities and support. The successful applicant will have a PhD in a relevant discipline (biology, bioinformatics, computer science etc) and ideally will have had either some training in a numerate discipline and/or experience with statistical analysis. S/he will have 3-5 years research experience in computational biology, molecular biology and/or bioinformatics, including a strong publication record. The ideal candidate will have experience in managing collaborative bioinformatics projects and will have in excess of 3 years experience in transcriptomics and microarray analysis. Experience with handling data for high-throughput technologies, such as microarrays, shotgun proteomics and/or deep-sequencing technologies would be a distinct advantage. The incumbant will also have 3 plus years experience of writing bioinformatics software in one or more of Perl, Java, C++ and Python and have 2 years experience of using statistical software packages, especially R/Bioconductor. A high level of Unix familiarity is required as is some experience of programming web interfaces and/or applications. Exposure to programming with relational databases and constructing SQL queries is also required. Experience of network modelling and analysis and managing staff and/or students is desirable. Excellent communication and interpersonal skills are essential An initial contract of 3 years will be offered to the successful candidate. This can be renewed, depending on circumstances at the time of review. For further information please visit http://www.embl.de and http://www.ebi.ac.uk EMBL is an inclusive, equal opportunity employer offering attractive conditions and benefits appropriate to an international research organisation. Note that special visa requirements apply to employees from non EU countries working at EMBL-EBI in the UK. The period of work does not qualify for the Highly Skilled Migrants Programme. To apply, please email a cover letter, CV (in English) and contact information of three professional references quoting ref. no. NS/09/094/EBI in the subject line, to: applications@ebi.ac.uk No agencies. http://www.newscientistjobs.com/jobs/job/data-integration-and-development-officer-cambridge-uk-bioinformatics-institute-united-kingdom-200630906.htmThu, 05 Nov 2009 14:48:19 +0000170006We are seeking a data integration and development officer to join the ChEMBL team at the EBI. The role is: • To be responsible for data modelling, handling and integration of external bioactivity to the ChEMBL databases. • To implement and apply data handling standards for the externally derived bioactivity data • To apply data mining techniques for the development of effective large-scale integration/curation strategies and define applicable standards. The role will involve requirement gathering, use-case development, database design/data modelling and statistical analysis. The data integration and development officer will report to the ChEMBL group coordinator. The ChEMBL group's research focuses on mapping the interactions and functional effects of small molecules binding to their macromolecular targets. The group studies the interactions of pharmacologically active molecules and their receptors. In particular the group builds and maintains a series of drug discovery databases that are components of ChEMBL. The European Bioinformatics Institute (EBI) is part of the European Molecular Biology Laboratory (EMBL) and is located on a greenfield campus with the Wellcome Trust Sanger Institute. The EBI provides world class data and analysis resources to the biological community. The successful applicant will have a minimum qualification of a BSc (or equivalent) in a technical subject (e.g science, computing or mathematics). A higher degree (MSc, PhD or equivalent) and postgraduate/postdoctoral experience is highly desirable. The ideal data integration and development officer is likely to have five or more years of postgraduate experience in areas of scientific data-mining, visualisation and analysis, database design or interrogation and application development, with a demonstrable track record of achievement. Formal training in data modelling, data mining, statistical methods, combined with training in programming/computational sciences is highly desirable but not essential. Relational database design, implementation, data handling/DBA skills would be beneficial. Prior experience of pharmaceutical data, chemical structures and biological sequences and screening data would be very desirable. The successful applicant must have a history of good practice in software engineering, rapid development cycle, and good code documentation. Experience of project management, in a matrix environment is required, as well as sound statistical practice and the ability to apply this in data mining and curation. The post-holder must have excellent knowledge of UNIX systems and a number of programming and scripting languages (e.g. Python, Perl, Java, etc). S/he should have good knowledge of relational databases (primarily Oracle) design and implementation, SQL and PL/SQL , web-services and Internet protocols. The data integration and development officer will be a team player who has the ability to work both as part of a team and independently. S/he will be self motivated with a drive for quality. Excellent communication (verbal and presentational) and interpersonal skills are a prerequisite. The successful candidate must have the ability to work to strict delivery deadlines. An initial contract of 3 years will be offered to the successful candidate. This can be renewed, depending on circumstances at the time of review. For further information please visit http://www.embl.org/ and http://www.ebi.ac.uk/. EMBL is an inclusive, equal opportunity employer offering attractive conditions and benefits appropriate to an international research organisation. Please note that special visa requirements apply to persons from countries outside the EU coming to work at EMBL-EBI in the UK. This period of work will not count as qualifying time in the Highly Skilled Migrant Programme. To apply, please email a cover letter, CV (in English) and contact information of three professional references quoting ref. no. NS/09/087/EBI in the subject line, to: applications@ebi.ac.uk. http://www.newscientistjobs.com/jobs/job/manager-biometrics-ne-nebraska-200632139.htmThu, 05 Nov 2009 13:50:46 +0000169885Assure compliance with reference qualification program standards and procedures; assist in experimental assay & clinical study design protocols to generate the best statistically relevant data package (i.e., reference curve calibration, reagent replacement, clinical study optimization, ELISA re-development including release and serology testing, and reference stability monitoring assays). Coordinate the data collection & write the mid-date reference stability report for submission to USDA. Provide a biometrics analysis where appropriate for data generated to support validation of processes, test methods, and to support clinical studies. Participate on Reference Qualification teams to provide biometrics support & obtain thorough understanding of study objectives. Defend the data and statistical analysis to internal management and to regulatory agencies. Participate in influencing the agency with regard to the appropriate statistical models for in-vivo and in-vitro studies. Qualifications: MS in Statistics with a minimum of 7 years of relevant experimental design and analysis experience. Experience in a science-based research or industry setting. Thorough understanding of experimental design and mixed linear/non-linear methodologies. General understanding of immunoassays and/or clinical study design. General understanding of contemporary & traditional bacteriology & virology techniques, and validation principles. In-depth knowledge of contemporary statistical analyses used to evaluate analytical & clinical studies. Demonstrated experience with SAS and possess excellent data management skills. Knowledge of USDA, FDA, and EU regulations, Good Manufacturing Practices (GMPs), Good Laboratory Practices (GLPs), and Good Clinical Practices (GCPs). Demonstrated ability to write and review technical documents with demonstrated high level of attention to detail. High integrity and self motivation. Strong communication (oral and written), interpersonal, and team/group interactive skills. Experience with communicating statistical analyses to a variety of skilled and unskilled audiences. Preferred Qualifications: PhD in Statistics with experience in biostatistical analyses of immuno-, biochemical, or molecular biological assays, and clinical studies. Experience with USDA biometrics standards and thorough knowledge of 9CFR 113.8 & reference qualification. Prior Lean methods training. Certified in RFT Six-sigma applications. Throughout our 153 years, a legacy of caring for others has been at the heart of everything we do at Pfizer. This commitment is no less important when it comes to our employees. Pfizer wants to ensure that employees have resources to help them develop and succeed both in their careers and personal lives. One way we can achieve this is through our comprehensive benefits program, which offers employees and their eligible dependents the variety and flexibility to help address their needs at different stages in life. Pfizer Inc. discovers, develops, manufactures, and markets leading prescription medicines for humans and animals. Our innovative, value-added products improve the quality of life of people around the world and help them enjoy longer, healthier, and more productive lives. The company has two business segments: health care and animal health. Our products are available in more than 150 countries. Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as employment eligibility verification requirements of the Immigration and Nationality Act. All applicants must possess or obtain authorization to work in the U.S. for Pfizer. Pfizer retains sole and exclusive discretion to pursue sponsorship for the acquisition or maintenance of nonimmigrant status and employment eligibility, considering factors such as availability of qualified U.S. workers. Individuals requiring sponsorship must disclose this fact. HOW TO APPLY: Please copy and paste the following URL into your browser address bar: http://posttrak.arbita.net/cgi-bin/PostTrak.cgi?RefCode=R2509125807948 http://www.newscientistjobs.com/jobs/job/career-development-fellow-bioinformatician-london-200631999.htmThu, 05 Nov 2009 12:22:43 +0000169686MRC LMCB & CBU Fixed term contract (3 years) The MRC Laboratory for Molecular Cell Biology is an internationally renowned molecular and cell biology institute situated in the heart of London at University College London (http://www.ucl.ac.uk/lmcb). Applications are invited for a bright and highly motivated Bioinformatician to join the Translational Research Resource Centre (TRRC) led by Dr Robin Ketteler. The TRRC is a newly established high-throughput screening laboratory located at the MRC LMCB in central London. We aim to perform genome-wide high-throughput RNAi screening and small molecule drug screening with an emphasis on image-based technologies and reporter-gene assays. The laboratory is equipped with cutting edge technologies and equipment. The successful candidate will be analyzing data from high-throughput screening experiments and developing tools for data handling and data mining of experimental data and published data in the scientific literature. The successful applicant will also interact with other researchers in the area performing high-throughput screening projects. Candidates should have a PhD in a relevant biomedical discipline and experience in bioinformatics that should ideally include navigating within molecular databases and analysis of imaging data. Experience in cell biology and/or molecular biology is desirable, with a background in high-throughput screening an advantage. Applicants should be willing to work independently and as a team so that they can undertake their own research projects and take an active role in ensuring the well-being and success of the research group as a whole. This will include training pre- and post-doctoral scientists and active participation in collaborative research projects. The post is funded for three years and is available immediately. Salary is on MRC band 4 from £29,663 to £35,399 inclusive and will be commensurate with skills and experience. Highly committed candidates are encouraged to contact me by email at r.ketteler@ucl.ac.uk. If you would like to receive this advert in large print, Braille, audio, or electronic format/hard copy, please contact the Recruitment Team at the MRC Shared Service Centre on 01793 301049 or recruitment@ssc.mrc.ac.uk Applications for this role must be made online by clicking the Apply Now button below. If you do not have internet access or experience technical difficulties, please call the number listed within the 'View Contact Details' section below, quoting reference number CBU09/572. Applicants should include a CV and a cover letter explaining why they would be a suitable candidate along with contact details for three referees. Closing date: 27th November 2009 The Medical Research Council is an Equal Opportunities Employer