Add

siRNA Formulations Scientist

Chemical and Pharmaceutical Profiling is seeking a scientist to integrate into the existing formulation/delivery group conducting research into the Novartis therapeutic siRNA initiative. Primary research goals will be drug delivery technology evaluation and application to the delivery challenge posed by therapeutic siRNA. Both systemic and local delivery methods will be explored for a diverse array of disease indications. Hands-on responsibilities will include the development of new formulation reagents, new oligonucleotide conjugation reagents, support the exploration of polymer-based delivery systems, and the development of predictive analytical and in vitro assays. Skills in tangential flow filtration, analytical/semi-preparative HPLC, and mass spectroscopy are desirable. Ability to provide technical consultation for complex projects and/or complex technical issues and will provide coaching and mentoring for associates. Can work independently and interact with a team of multidisciplinary backgrounds including medicinal chemistry, biologists, pharmacologists, and external collaborators. Excellent oral and written communication and presentation skills. Specific experience with development of polymer-based/lipid gene delivery systems and/or oligonucleotide analytical development is desirable.