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Prin Res Sci, Carbohydrate & Conjugates, Vaccine Research Early Development

As a member of Vaccine Research East – Early Development group, the qualified candidate will be responsible for developing and qualifying analytical methods (in line with ICH guidelines) using industry leading technologies for characterization and release of polysaccharides, proteins, glycoconjugates and their intermediates. The candidate will work across multiple analytical functions and cross functional project teams. The candidate will also serve as technical counsel to senior leadership and is expected to train and mentor other scientists.

- Development of assays for characterization of polysaccharides, proteins, conjugates and potential process residuals.
- Development of in-process assays to support process development for polysaccharide expression, purification, monitoring of conjugation processes and glycoconjugate purification.
- Design and development of analytical assays for testing the stability of polysaccharides and glycoconjugates.
- Execution of assays qualification and the transfers of developed methods.
- Development of technologies with a focus on gaining insight into sites of conjugation in polysaccharide and protein components of glycoconjugates.
- Author reports, technical documents, generate appropriate documentation for transfer of the methods
- Contribute portions of patents, regulatory documents or manuscript as required
- The candidate will also train staff in specific technologies and supervise their work as needed.
- Maintain a safe and productive work environment. Maintain an accurate and reliable laboratory notebook. Maintain broad overview of relevant scientific literature

Education & Experience:
- Ph.D. in Organic Chemistry, Analytical Chemistry or related field + 4-years experience.
- 2+ years of industrial experience in assay development are required..
- The candidate should have expertise in physicochemical and structural characterization of complex carbohydrates, physicochemical characterization of glycoconjugates.
- Knowledge and practical experience in the analytical assay development and assay qualifications.
- Extensive experience in the development of novel protocols and methods using the following technologies, i.e. LC-MS, GC-MS, NMR, MALS/AFFF and HPAEC-PAD.
- Publications and/or patents are a must.
- Experience in training analytical scientists in a team environment.
- Experience with ICH guidelines is desirable.

Technical Competencies:
- Independent planning.
- Practical experience in liquid chromatography, LC-MS, GC MS, MS, NMR, HPLC, MALS/AFFF and HPAEC PAD is required.
- Structural characterization of complex carbohydrates, linkage analysis is required.
- Good communication/presentation and writing skills are required.

Behavioral Competencies:
- Good communication/presentation and writing skills are required.


Benefits:
At Pfizer, we've long recognized that our colleagues are our most important asset. We value our colleagues, recognize their talent, encourage their growth and reward their performance. It's a terrific environment that enables people to contribute, to do their best, and to achieve their potential.

Throughout our history, a legacy of caring for others has been at the heart of everything we do at Pfizer. This commitment is no less important when it comes to our employees.

When you choose a Pfizer career, we provide the resources to help you develop and succeed both in your career and your personal life. One way we can achieve this is through our comprehensive benefits program, which offers employees and their eligible dependents the variety and flexibility to help address their needs at different stages in life.


Company Profile:
Pfizer Inc: Working together for a healthier world

Founded in 1849, Pfizer is the world's premier biopharmaceutical company taking new approaches to better health. We discover, develop, manufacture and deliver quality, safe and effective prescription medicines to treat and help prevent disease for both people and animals. We also partner with healthcare providers, governments and local communities around the world to expand access to our medicines and to provide better quality health care and health system support. At Pfizer, colleagues in more than 90 countries work every day to help people stay happier and healthier longer and to reduce the human and economic burden of disease worldwide.

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status.


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