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Formulation Associate

A leader in therapeutic antibodies, ImClone Systems is committed to advancing oncology care by developing a portfolio of novel targeted biologic treatments designed to address the medical needs of patients with a variety of cancers. Founded 25 years ago, ImClone Systems has a rich culture of biotechnology innovation and leading-edge medical science. Our deep expertise in molecular biology, oncology, genomics and antibody engineering has helped us establish a robust pipeline of products that are in various stages of clinical development and span virtually all major solid tumor types.

The Formulation Associate will be responsible for assisting in the development of formulations for protein therapeutics, to include buffer preparation, stability studies and investigations for compatibility and delivery problems.

ESSENTIAL DUTIES AND RESPONSIBILITIES
1. Operation of Spectrophotometer, pH meter, Conductivity Meter and Electrophoresis Apparatus (i.e. SDS-PAGE, IEF)
2. Operation of analytical HPLC (SEC, IEC and RP)
3. Assists in the development of analytical methods for protein analysis
4. Buffer preparation
5. Perform routine assays to test the chemical stability of proteins in relation to excipients and storage conditions
6. Data entry
7. Assay development and trouble shooting
8. Assist in the development of final drug dosage forms
9. Maintain Laboratory and Laboratory Records
10. Work in a safe manner and be compliant to ImClone Systems policies and procedures

ESSENTIAL KNOWLEDGE, SKILLS, EXPERIENCE
1. BS with 2-6 years of experience, MS with 1-4 years of experience
2. Knowledge of the use of and experience with spectrophotometry, electrophoresis (SDS-PAGE and IEF), HPLC.
3. Knowledge of protein chemistry with experience in protein sample analysis and handling.
4. Knowledge and experience in buffer preparation.
5. Knowledge of and operation of biophysical analytical instrumentation will be a plus (Fluorimeter, DSC, HIAC, DLS and Osmometer).